NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti …

CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes tumor progression by suppressing antitumor immune response and promoting angiogenesis.

CD73 shows varied tissue expression, predominantly in the colon, kidneys, brain, liver, heart, lungs, spleen, lymph nodes, and bone marrow. In the vascular system, CD73 primarily …

The initial results suggest that inhibiting CD73 could be an effective option to augment anti-cancer immunotherapeutic strategies. This review provides an overview of the rationale behind the …

4 天之前 · CD73 is a member of the membrane-bound enucleotidase family, which catalyzes the extracellular hydrolysis of adenosine monophosphate (AMP) to produce anti-inflammatory and …

CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive …

2023年3月2日 · The sequential conversion of extracellular ATP into adenosine by two important cell-surface ectonucleosidases CD39 and CD73 play critical roles in reshaping an …

2 天之前 · The function of CD73 (Cluster of Differentiation 73), an enzyme involved in the formation of adenosine (ADO), in the development of glioblastomas has been demonstrated. …

2025年3月19日 · Article Open access Published: 19 March 2025 Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential …

6 天之前 · Explore how CD73 inhibitors regulate immune responses by targeting adenosine production, with insights into inhibitor types and efficacy assessment methods.