2025年3月18日 · CD66b is a cell surface glycoprotein primarily expressed on neutrophils, playing a key role in immune responses. It helps distinguish neutrophils from other leukocytes, making it an important biomarker in research and clinical diagnostics.

The CD66b + monocytes displayed high phagocytic activity, matrix adhesion and migration, and provided costimulation for T cell proliferation and IFN-γ secretion; thus, they did not suppress T cell responses.

Directly isolated neutrophils express very high levels of CD66b. It is also expressed by eosinophils. See supplemental figure S4H in this recent Immunity paper

CD66b, a granulocyte activation marker typically found on neutrophils and eosinophils, may have predictive value in patients treated with immunotherapy.

CD66b, expressed on granulocytes, has been reported to induce activation in neutrophils and to be involved in heterophilic adhesion with CD66c. The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.

2007年12月15日 · CD66b (CEACAM8, CGM6, NCA-95) is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic Ag supergene family. CD66b is an activation marker for human granulocytes; however, its …

CD66b is thought to play a role in the regulation of the adhesive activity of CD11/CD18 via signal transduction in neutrophils. It is strongly expressed by myelocytes, metamyelocytes, neutrophils and polymorphonuclear neutrophils. CD66b is weakly expressed by promyelocytes.

Neutrophils express several heavily glycosylated carcinoembryonic antigen (CEA)-related glycoproteins (CD66 antigens) which have been implicated in adhesion to E-selectin and as receptors for the lectins galectin 3 and bacterial type-1 fimbriae.

For correlation of the CD66b molecule expression with the phagocytosis data we examined the relative upregulation of CD66b and the corresponding phagocytosis rate after preincubation with SaS A. The results demonstrated that the molecule can be directly correlated to phagocytic activity (Fig 3B).

CD66a, CD66b, CD66c, and CD66d antibodies each increased neutrophil adhesion to human umbilical vein endothelial cell monolayers. This increase in neutrophil adhesion caused by CD66 antibodies was blocked by a CD18 antibody and associated with up-regulation of CD11/CD18 on the neutrophil surface.