CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain.

2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression.

2014年2月10日 · In this analysis of approximately 3,000 patients, CD49d emerged as the strongest flow cytometry–based predictor of OS and TFS in CLL.

CD49d is a surface subunit of the integrin heterodimer that is involved in promoting survival of the CLL cells through microenvironment derived growth signals. CD49d can be used as a reliable predictive marker of aggressive disease course and inferior survival is associated with ≥30% cells expressing CD49d by flow cytometry.

2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression.

CD49d (integrin alpha 4) plays a critical role in leucocyte trafficking, activation, and survival, and also facilitates interactions between leucocytes and stromal cells found in the marrow or germinal center of lymphoid follicles via VCAM-1 and fibronectin (Rose et al, 2002).

2010年7月1日 · We found CD49d (VLA4), a member of the integrin α-chain family of proteins, to be exclusively expressed on CD11b + Gr-1 dull/int cells. CD49d is composed of a α4 (CD49d) and a β1 (CD29) chain and serves as a receptor for fibronectin and VCAM-1 (VCAM-1, CD106).

CD49d can be an activation marker, but more generally, appears to define a distinct subset of CLL. Observations linking CD49d expression to cell activation include increased frequency of CD49d+ cells in bone marrow, compared to peripheral blood, and in the CXCR4dim/CD5 bright fraction of recent emigrants from lymphoid tissues [6, 33].

2016年4月25日 · CD49d, the alpha-chain of the integrin heterodimer α4β1, was identified among the strongest predictors of overall survival (OS) in chronic lymphocytic leukemia (CLL), along with IGHV...

2008年1月15日 · CD49d, whose expression was strongly associated with that of CD38 (P < .001) and ZAP-70 (P < .001), or with IGHV mutations (P < .001), was independent prognosticator for overall survival along with IGHV mutational status (CD49d hazard ratio, HR CD49d = 3.52, P = .02; HR IGHV = 6.53, P < .001) or, if this parameter was omitted, with ZAP-70 (HR ...