Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). [5] Multiple transcript variants encoding …

CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor. A protein found on the surface of many different types of cells. It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow.

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.

CD117, also known as c-kit, is a protein that acts as a receptor on the surface of specific cells in the body. It is involved in cell growth, survival, and development, particularly in cells that form part of the blood, skin, and digestive system.

CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast cell disorders and identification of myeloblasts in acute leukemias.

2019年2月6日 · Here we show that a single dose of a CD117-antibody-drug-conjugate (CD117-ADC) to saporin leads to > 99% depletion of host HSCs, enabling rapid and efficient donor hematopoietic cell...

CD117, the c-kit proto-oncogene product, is expressed in subsets of hematopoietic stem cells, mast cells, melanocytes, and interstitial cells of Cajal of the GI tract. CD117 was almost always (85%) expressed in both benign and malignant GISTs.

2019年11月13日 · The CD117 (c-KIT) receptor tyrosine kinase is expressed on the cell surface of hematopoietic stem cells and its signaling is important in cell survival, proliferation and differentiation. CD117 is expressed in a majority of AML cases.

CD117 is an important cell surface marker used to identify certain types of hematopoietic (blood) progenitors in the bone marrow. To be specific, hematopoietic stem cells (HSC), multipotent progenitors (MPP), and common myeloid progenitors (CMP) express high levels of CD117.

CD117 develops an overactivation or ligand-independent constitutive mutation to become oncogenic. Overactivation of CD117 causes alterations in the signaling pathways upregulating proliferation, cell survival, migration, and differentiation.