2024年12月24日 · CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

CCL5/CCR5 axis promotes VEGF production by attracting endothelial progenitor cells (EPCs). The CCL5-overexpressing-osteosarcoma makes EPCs migrate to abnormal sites.

Introduction: Chemokines play important roles in inflammation and in immune responses. This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and whether it is a therapeutic target in the context of various allergic, autoimmune or infectious diseases.

2021年6月9日 · CCL5，CC类趋化因子配体5，也称为调节激活正常T细胞表达分泌因子（RANTES），是一种能使白细胞作定向移动的小分子分泌蛋白。 CCL5来源广泛，如NK、T、巨噬细胞、滑膜成纤维细胞，炎症反应中的CD8+ T细胞、上皮细胞、成纤维细胞和血小板，病毒感染后的细胞，以及某些肿瘤细胞。 CD40、IL-15等不同刺激物激活NF-kB会诱导CCL5的产生。 …

2024年9月27日 · Our findings demonstrate the significant potential of CCL5 as an immunotherapeutic response biomarker and prognostic indicator, which may pave the way for more studies on the mechanism of tumor...

CCL5 (also RANTES) is a chemokine that provides activating and chemotactic signalling to T lymphocytes, basophils and eosinophils of the peripheral immune system (Murphy et al., 2000). In the CNS, CCL5 is constitutively expressed by microglia …

CCL5's Role in Periodontal Disease: A Narrative Review. Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor alpha gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants.

2021年4月30日 · CCL5 promotes aerobic glucose metabolism, mitochondrial ATP generation and purine synthesis, improving synaptic plasticity and enhancing memory and cognition functions.

This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies aimed to inhibit the binding of CCL5 to CCR5, to inhibit CCL5 secretion, or to inhibit the ...

Chemokine ligand 5 (CCL5), a vital member of the CC chemokine family, plays diverse roles in tumorigenesis, metastasis, and prognosis in various human tumors. However, no pan-cancer analysis has been conducted to illustrate its distinctive effects on clinical prognosis via underlying mechanisms and biological characteristics.