CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated …

2024年12月24日 · CCL21 (C-C Motif Chemokine Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include Periapical Periodontitis and Scrapie. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity and CCR7 chemokine receptor …

2021年7月23日 · CCL21 is constitutively expressed by lymphatic endothelial cells and is essential for guiding DCs to the lymph nodes. Two mouse genes encode functional CCL21 variants, CCL21-Ser and CCL21-Leu.

CCL21 is a homeostatic chemokine constitutively produced in secondary lymphoid organs (SLOs) where it is involved in CCR7 + naïve and central memory T-cell homing via high endothelial venules (HEVs).

CCL21/CCR7 prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax and caspase-3 potentially via the ERK pathway in non-small cell lung cancer cell lines; CCL21 was more localized to chondrocytes and meniscal cells during the development of osteoarthritis in mice.

CCL21 is a risk factor for Rheumatoid arthritis (RA). CCL21 is highly elevated in RA synovial fluid and attracts circulating monocytes into the inflamed joint. CCL21 differentiates monocytes into a unique subtype of macrophages.

In this review we discuss our experience with efforts to restore host APC and T cell activities in the lung cancer microenvironment by intratumoral administration of dendritic cells (DC) expressing the CCR7 receptor ligand CCL21 (secondary lymphoid chemokine, SLC).

In rheumatoid arthritis (RA), synovial tissue abundantly expresses CCL21, a chemokine strongly associated with RA susceptibility. In this study, we aimed to characterize the functional significance of CCL21/CCR7 signaling in different phases of RA pathogenesis.

2016年1月1日 · CCL21 mediates the recruitment and co-localization of naive lymphocytes and antigen-stimulated DC into T-cell zones of secondary lymphoid organs, facilitating T-cell activation. In this chapter, we discuss CCL21 as a novel agent to …

2006年9月14日 · CCL19/CCL21 regulates immune responses not only by attracting leukocytes but also by providing signals for modifying T-cell fate, seeming to promote the differentiation of naive CD4 + T cells into effector cells after antigen stimulation.