C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases. The first Raf gene, v-Raf was found in 1983. It was isolated from the murine retrovirus bearing the number 3611.

2024年1月9日 · Here, we summarize the main known regulatory mechanisms and gene alterations that contribute to CRAF activity, highlighting the different oncogenic roles of CRAF, and categorize RAF1 (CRAF)...

2011年5月16日 · Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be...

2024年5月16日 · The C-RAF is a risk-based framework for Authorized Institutions ("AIs") to assess their own risk profiles and benchmark the level of defence and resilience that would be required to accord appropriate protection against cyberattacks. The inherent risk assessment comprise five categories.

C-Raf is a serine/threonine kinase that is part of the Raf family, which is activated by ras-GTP and/or PKC-α. It plays a crucial role in transducing signals along the Ras-Raf-MEK-ERK pathway, making it a potential target for anticancer therapy, especially in tumors with activating mutations in …

RanBPM is part of a recently identified E3 ubiquitin ligase complex, the CTLH (C-terminal to LisH) complex. Here, we show that the CTLH complex regulates c-Raf expression through a control of its degradation.

2023年12月18日 · Overall, the present review aims to explore the role of CRAF in cancer and highlights recent advances in RAF inhibitor combination therapies to improve treatment efficacy and mitigate toxicities in patients with RAF/RAS -mutant tumors.

2024年4月18日 · Herein, we demonstrate how a novel cell-penetrating peptide disruptor (DRx-170) of the c-RAF–PDE8A protein–protein interaction (PPI) represents a differentiated approach to exploiting the...

The c-Raf-1 protein kinase plays a critical role in intracellular signaling downstream from many tyrosine kinase and G-protein-linked receptors. c-Raf-1 binds to the proto-oncogene Ras in a GTP-dependent manner, but the exact mechanism of activation of c-Raf-1 by Ras is still unclear.

This review addresses the rationale for targeting raf, the diverse cellular functions regulated by c-raf, and the current status of various pharmacological approaches targeting c-raf.