2021年3月29日 · B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It belongs to the CD28 superfamily and is similar to programmed cell death-1 (PD-1) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) in terms of its structure and function.

2021年3月28日 · BTLA can be detected in most lymphocytes and induces immunosuppression by inhibiting B and T cell activation and proliferation. The BTLA ligand, herpesvirus entry mediator (HVEM), does not belong to the classic B7 family. Instead, it is a member of the tumor necrosis factor receptor (TNFR) superfamily.

2024年1月17日 · In preclinical studies, BTLA-targeted therapies have shown improved treatment outcomes and enhanced antitumor immunity. This review aims to provide an in-depth understanding of BTLA’s biology, its role in various cancers, and its …

2024年12月24日 · BTLA (B And T Lymphocyte Associated) is a Protein Coding gene. Diseases associated with BTLA include Hematologic Cancer and Rheumatoid Arthritis . Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and …

B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance ...

2016年11月15日 · Importantly, B- and T-lymphocyte attenuator (BTLA), an immunoglobin domain superfamily protein, is specifically expressed in DEC205 + CD8 + DCs. Therefore the authors speculated that DCs required BTLA to induce Treg cells.

The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamily member. BTLA engagement results in downregulation of T-cell activation, and mice deficient in BTLA show increased incidence and severity of autoimmune disorders.

Checkpoint receptors, such as B and T lymphocyte attenuator (Btla), are widely expressed in lymphocyte and myeloid cells, where they function to regulate innate and adaptive immune responses and prevent the development of autoimmune disease (Schildberg et al., 2016; Ward-Kavanagh et al., 2016; Zhang and Vignali, 2016).

2024年1月17日 · B and T lymphocyte attenuator (BTLA) is one of crucial checkpoint, regulating stimulatory and inhibitory signals in immune responses. Its interaction with the herpes virus entry mediator (HVEM) plays an essential role in negatively regulating immune responses, thereby preserving immune homeostasis.

2003年6月8日 · During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin...