Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene [5] which is located on the X chromosome.

Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the …

Biglycan is a core protein with leucine-rich repeats and chondroitin/dermatan sulfate side chains, found in the extracellular matrix of various tissues. It plays a key role in regulating collagen fibril assembly and interacts with cytokines to modulate diverse biological functions.

2021年6月28日 · Biglycan, a class I small leucine-rich proteoglycans (SLRP), is a key component of the ECM that participates in scaffolding the collagen fibrils and mediates cell signaling.

We propose a novel concept of hepatorenal crosstalk, that is, biglycan produced by the cirrhotic liver could constitute a circulating "messenger" for the kidneys triggering inflammation and/or autophagy ultimately affecting disease outcome.

2021年6月1日 · The role of soluble biglycan in regulating both pro- and anti-inflammatory response is prototypically illustrated by its regulation of the pro-inflammatory master cytokine IL-1β. Biglycan, on one side, directly triggers pro-IL-1β production via TLR2/4 [49].

Biglycan is a small proteoglycan encoded by the X-linked BGN gene (Table 1, Figure 1). It consists of a protein core comprising ten leucine-rich repeats, to which either two N terminal chondroitin (in bone) or dermatan sulfate (in soft connective …

Background and objective: Decorin, biglycan, fibromodulin and lumican are structurally related molecules that belong to the family of small leucine-rich proteoglycans (SLRPs). These SLRPs are secreted extracellular matrix molecules that interact with type I …

Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically thought to promote macrophage recruitment via Toll-like receptors (TLR) 2 and 4.

Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the …