BBSome - Wikipedia
A BBSome is a protein complex that operates in primary cilia biogenesis, homeostasis, and intraflagellar transport (IFT). [1] The BBSome recognizes cargo proteins and signaling …
Structure of the human BBSome core complex - PubMed
2020年1月17日 · Here we present a high-resolution cryo-EM structure of a human heterohexameric core subcomplex of the BBSome. The structure reveals the architecture of …
The BBSome: Current Biology - Cell Press
2009年6月23日 · What is the BBSome? The BBSome (pronounced bee-bee-zome) is a stable protein complex that functions in primary cilium biogenesis.
Organization, functions, and mechanisms of the BBSome in ... - eLife
2023年7月19日 · Bardet-Biedl syndrome (BBS) is a rare, pleiotropic inherited autosomal recessive disorder characterized by retinal dystrophy, obesity, polydactyly, structural and functional renal …
Organization, functions, and mechanisms of the BBSome in …
The BBSome is an octameric protein complex that regulates ciliary transport and signaling. Mutations in BBSome subunits are closely associated with ciliary defects and lead to …
The BBSome: a nexus controlling energy metabolism in the brain
Bardet-Biedl syndrome (BBS) is a syndromic ciliopathy that has obesity as a cardinal feature. BBS is caused by mutations in BBS genes. BBS proteins control primary cilia function, and BBS …
Structure of the human BBSome core complex - eLife
2020年1月17日 · Here we present a high-resolution cryo-EM structure of a human heterohexameric core subcomplex of the BBSome. The structure reveals the architecture of …
The BBSome assembly is spatially controlled by BBS1 and BBS4 in …
2020年10月10日 · Bardet–Biedl syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of primary cilia. More than half of BBS patients carry mutations in one of eight genes encoding …
The BBSome regulates mitochondria dynamics and function
2022年12月10日 · Our data show that the BBSome play an important role in the regulation of mitochondria dynamics and function. Disruption of the BBSome cause mitochondria …
Loss of the BBSome perturbs endocytic trafficking and disrupts ...
2016年1月19日 · Using BBS gene knockouts and a mouse infection model, we show the T. brucei BBSome is dispensable for flagellar assembly, motility, bulk endocytosis, and cell viability but …