BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. [ 5 ] [ 6 ] [ 7 ] The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and a tandem BRCT domain (residues 568-777).

2023年7月17日 · While a BARD1 mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives have cancer. As we learn more about these mutations, we may learn they …

Women who carry mutations in the BARD1 gene may be more likely to develop breast cancer and possibly ovarian cancer. Here’s what you need to know about this cancer risk gene.

2024年12月24日 · BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Inherited Cancer-Predisposing Syndrome. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.

In light of this new evidence, the National Comprehensive Cancer Network (NCCN) now recommends that those with a BARD1 pathogenic variant consider annual breast MRIs in addition to regular annual mammograms starting at age 40.

2025年3月7日 · An inherited BARD1 mutation may affect your options for breast cancer prevention, detection and treatment. FORCE is here to guide you.

2022年6月22日 · BARD1, as a BRCA1 heterodimer interactor that plays an essential role as a tumor suppressor gene altered in breast and ovarian cancers, was also found to display a BRCA1-independent function during cancer progression.

2025年3月7日 · The PARP inhibitor, Lynparza (olaparib) has FDA-approval to treat metastatic, castration-resistant prostate cancer in people who have a mutation in BARD1 or other genes linked to a certain type of DNA damage repair.

2025年3月16日 · Title: BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes. Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.

2020年7月27日 · Sequencing analyses revealed that potentially pathogenic BARD1 variants likely conferred a low-moderate risk to hereditary breast cancer, but this association is inconsistent. Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cancer risk genes for hereditary breast and/or ...