ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein that in humans is encoded by the ARL13B gene. [5][6] This gene …

2024年12月24日 · ARL13B (ARF Like GTPase 13B) is a Protein Coding gene. Diseases associated with ARL13B include Joubert Syndrome 8 and Joubert Syndrome 1 . Among its …

We show Arl13b is localized to the ciliary membrane and regulates tubulin modifications and ciliary length in vitro. Significantly, we found that Smoothened is enriched in Arl13b null …

2025年1月4日 · ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E. Biochemical characterization of purified mammalian …

2019年2月20日 · ADP ribosylation factor-like GTPase 13B (Arl13b) is a member of the Arf-like Ras superfamily of small GTPases. Small GTPases serve as molecular “switches” that cycle …

Arl13b was initially identified as a candidate that potentially plays a role in multiple ciliated organs in zebrafish [50,51]. Arl 13 bhnn mouse embryos show ciliopathy defects in neural tube …

2015年11月23日 · The ARL13B gene encodes a member of the ADP-ribosylation factor-like (ARL) family of small GTPases of the RAS superfamily. ARL13B is required for proper cilia …

2019年2月20日 · Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to photoreceptor impairment and vision loss. To determine the role of ARL13B in the …

ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B …

2024年10月10日 · Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria. Domain architecture of the …