Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin …

而到了 M期，起到关键调节作用的则是后期促进复合物/环体 （anaphase promoting complex/cyclosome ，APC/C）。 APC/C属于 E3泛素连接酶，通过泛素化作用靶向降解特定的蛋白，包括Cyclin B和Securin蛋白，来完成最后的细胞分裂。

2019年5月23日 · The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle.

“后期促进复合物/细胞周期体” (APC/C)是一种大型E3连接酶，介导细胞周期调控蛋白的依赖于泛素的蛋白水解，以在复制和细胞分裂过程中控制各种事件。

细胞周期调控的一个重要方面是由多蛋白E3泛素连接酶复合物控制的，如促进无效复合物或细胞周期体（APC/C）、Skp-Cullin-F box复合物和BTB-Cul3-Rbx1复合物（BCR），它们依次促进关键细胞周期调节器的降解（图3）。

2015年6月15日 · The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit.

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new perspective on the connection between APC/C subunit …

2025年3月15日 · The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying ...

2004年9月21日 · Two related E3 complexes are most intimately dedicated to basic cell-cycle control, namely the anaphase-promoting complex or cyclosome (APC/C), and the SCF (Skp1/cullin/F-box protein)-related complexes. In this review, I will thus focus on their roles in the cell cycle, on their regulation, and on the interplay between them.

在对APC/C进行质谱分析时发现SUMO2/3结合的乳酸依赖性升高，且16种蛋白质在乳酸处理后均表现出SUMO2/3的显著升高，说明乳酸对SUMO2/3通路有针对性的影响。