2024年12月24日 · ADAM8 (ADAM Metallopeptidase Domain 8) is a Protein Coding gene. Diseases associated with ADAM8 include Asthma. Among its related pathways are Innate Immune System and Extracellular matrix organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity.

The expression of ADAM8 in brain metastases from various primary malignancies has been investigated, and ADAM8 has been found to be elevated in brain metastases derived from primary breast cancer and to aid transmigration across the endothelium and blood-brain barriers.

2025年2月8日 · Blood ADAM 8 is a promising biomarker for early detection of gastric cancer. ADAMs binds to integrins to regulate cell adhesion and migration. ADAM8 is a marker of residual CML cells.

2023年12月14日 · ADAM8, also known as MS2/CD156a, is one such protease, and due to its structural and functional characteristics, ADAM8 can exert multiple (pathological) functions. Since the functions of ADAM8 go far beyond that of a shedding enzyme, we summarize here all observations made in the context of homeostasis and pathology over the last decades.

ADAM8 is identified as an antigen of TKI-resistant CML cells • The inhibition of ADAM8 restored TKI sensitivity in primary samples • ADAM8 is a marker of residual CML cells in patients with optimal TKI response

ADAM8 was originally cloned from monocytic cells, and its distinct expression pattern indicates possible roles in both immunology and neuropathology. Here we describe our analysis of its biochemical properties.

In this review, we report on available studies that qualify ADAM8 as a therapeutic target in different pathologies. As a signaling hub, ADAM8 controls extracellular, intracellular, and intercellular communication, the latter one mainly mediated by the release of extracellular vesicles with ADAM8 as cargo.

2022年2月10日 · In recent studies, A disintegrin and metalloprotease 8 (ADAM8) was identified as an extracellular metalloprotease-disintegrin important for tumor progression, invasion, and metastasis in pancreatic ductal adenocarcinoma (PDAC) [ 2 ]. PDAC is one of the most lethal solid tumors with a 5-year survival rate of less than 8%.

We propose that in acute inflammatory lung diseases such as pneumonia and ARDS, ADAM8 inhibition might allow fine-tuning of neutrophil responses for therapeutic gain. Keywords: Inflammation, Pulmonology. Keywords: Innate immunity, Neutrophils, Proteases.

ADAM8 levels are increased in airway epithelium and airway inflammatory cells in mice with AAI and human asthma patients. Data from murine models of AAI indicate that ADAM8 dampens airway inflammation.