2024年12月24日 · ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Diseases associated with ACKR1 include White Blood Cell Count Quantitative Trait Locus 1 and Malaria. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Atypical chemokine receptor 1 (ACKR1), previously known as the Duffy antigen receptor for chemokines (DARC), is a key regulator that binds chemokines involved in inflammatory responses and cancer proliferation, angiogenesis, and metastasis.

2024年9月20日 · The ACKR1 gene encodes the Duffy antigen receptor for chemokines (DARC), which is expressed on red blood cells (RBCs), endothelial cells, and other cell types.

2025年3月8日 · Title: Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles. Presence of ""ACKR1/DARC null"" polymorphism in Arabs from Jisr az-Zarqa with benign ethnic neutropenia.

2013年10月11日 · Atypical chemokine receptors (ACKRs) are structurally related to conventional chemokine receptors but are unable to initiate classical chemokine receptor signalling after ligand binding.

2024年5月7日 · There are four receptors currently with formal ACKR designation: ACKR1 (formerly known as Duffy antigen receptor for chemokines (DARC)), ACKR2 (formerly known as D6 or CCBP2), ACKR3 (also known...

Here we demonstrate that Ackr1 (-/-) mice have markedly impaired balance and ataxia on a rotating rod and increased tremor when injected with harmaline, which induces whole-body tremor by activating Purkinje cells.

2015年6月4日 · Recently, a new nomenclature for atypical non-signaling chemokine receptors such as DARC was adopted and approved and DARC is now known by the acronym ACKR1 (atypical chemokine receptor 1) However, for the purpose of this review, we will stick to the old nomenclature of DARC.

2024年9月24日 · Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

2017年9月4日 · ACKR1, also known as Duffy antigen receptor for chemokines, is expressed in endothelial cells (ECs), erythrocytes and a subset of neurons. 4 On ECs, ACKR1 regulates inflammatory responses by...