2024年12月24日 · ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with ASCL1 include Haddad Syndrome and Congenital …

2022年4月27日 · ASCL1 acts as a driver of the lineage plastic, neuronal transcriptional program to support treatment resistance and neuroendocrine phenotype. Targeting ASCL1 switches …

2016年8月2日 · Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci, and regulate mostly distinct genes. ASCL1, but not NEUROD1, is …

2025年2月8日 · Ascl1 modulates multiple steps of oligodendrocyte precursor cell development in the postnatal brain and in response to demyelinating insults. Ascl1 directly regulates …

ASCL1, also known as a proneural bHLH transcription factor, is a protein that is expressed in oligodendrocyte progenitor cells (OPCs) during both embryonic and early postnatal stages. It …

2019年5月13日 · We found that Ascl1 and Neurog2 generate neurons by binding to largely different sets of genomic sites when expressed in similar chromatin and cellular contexts. …

2014年10月14日 · We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the …

2024年11月28日 · In this study, we show that ASCL1 and OLIG2 can physically and genetically interact to bind to similar sites in the genome of two separate patient-derived-orthotopic GBM …

2015年3月10日 · We identify a large number of genes directly regulated by Ascl1 and characterize widespread changes in chromatin accessibility during differentiation. Ascl1 …

2025年1月4日 · Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and …