Principles of the activin receptor signaling pathway and its …
2021年8月1日 · ALK4, ALK5, or ALK7 antagonism pivots around small-molecule inhibitors. The small-molecule inhibitors work by occupying the adenosine triphosphate binding site of the …
ALK Gene - GeneCards | ALK Protein | ALK Antibody
2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related …
Activin receptor-like kinases: a diverse family playing an important ...
ALK4 Function. ALK4 (ACVR1B) is a versatile receptor that has a critical role in development. In Xenopus, ALK4 activates both sides of the developmental pathway: the TGFβ-driven left side …
New function of the myostatin/activin type I receptor (ALK4) as a ...
Antisense oligonucleotides (AONs) were designed specifically to block the function of ALK4, a key receptor for the MSTN/activin pathway in skeletal muscle. AON-induced exon skipping …
Perspectives of small molecule inhibitors of activin receptor …
The truncated form of ALK4 functions as a dominant negative inhibitor of activin signaling and eliminates the growth suppression induced by activin , while the overexpression of wild-type …
ALK4/5-dependent TGF-β signaling contributes to the crosstalk
2019年5月3日 · The present results show that neurons and microglia both use ALK4/5 (a type of TGF-β receptor) signaling in order to maintain mutual exchanges in an adult brain following an …
91 - Gene ResultACVR1B activin A receptor type 1B [ (human)]
2025年2月8日 · ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF …
Reduction of Activin Receptor-Like Kinase 4 Expression …
The activation of activin receptor-like kinase 4 (ALK4) signaling plays a pivotal role in the pressure-overloaded heart, and haplodeficiency of ALK4 can alleviate cardiac fibrosis …
ALK4 functions as a receptor for multiple TGF beta-related ... - PubMed
2004年4月15日 · We report here that similar to effects of ectopic TGF betas, right-side expression of constitutively active activin-like kinase (ALK) 4 results in LR organ reversals as well as …
ALK4 coordinates extracellular and intrinsic signals to regulate ...
2020年1月1日 · Göngrich et al. show that the activin receptor ALK4 is a key regulator of the specification of somatostatin interneurons. They find that intrinsic transcriptional programs …
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