The 26S proteasome is the major protease in eukaryotic cells, responsible for protein degradation in both the cytosol and the nucleus. Ubiquitin modifications target condemned proteins to the …

2018年6月20日 · As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells.

2016年7月22日 · The 26S proteasome is a large, ∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major …

2024年10月3日 · The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a sophisticated balance of specificity and …

The 26S proteasome is a large multi-protein complex involved in the regulated degradation of ubiquitinated proteins in the cell. The 26S proteasome has been shown to control an …

The 26S proteasome is the essential compartmental protease in eukaryotic cells required for the ubiquitin-dependent clearance of damaged polypeptides and obsolete regulatory proteins.

The 26S proteasome is the most complex ATP-dependent protease machinery, of ~2.5 MDa mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The 26S proteasome catalyzes the great majority (at least 80%) of the protein degradation in growing mammalian cells, including both the rapid degradation of misfolded and regulatory …

2008年8月8日 · Here we describe the three-dimensional structure of the human 26S proteasome, doubly capped with 19S-RPs, determined by single particle analysis of electron microscopy …

In all eukaryotic cells, 26S proteasome plays an essential role in the process of ATP-dependent protein degradation. In this review, we focus on structure characterization of the 26S proteasome.