为探究 TP53 状态对 LGG 患者的影响，研究人员分析数据，发现野生型 TP53 关联不良结局等，具预测潜力。 低级别胶质瘤（LGG）是起源于大脑支持细胞（神经胶质细胞）的恶性脑肿瘤，在儿童和青少年的中枢神经系统肿瘤中最为常见，约占所有病例的一半。肿瘤蛋白 p53（TP53）通过多种细胞周期、细胞凋亡和基因组稳定性途径来调节或促进 DNA 损伤修复。然而，TP53 状态在 LGG 患者中的临床 ...

体内实验表明，沉默 LEF1-AS1 可通过 CEBPB - CDCA7 信号通路下调 EZH2，抑制 HCC 细胞生长。 在对 56 例 HCC 组织和细胞系的研究中发现，LEF1-AS1 和 Musashi1（MSI1）表达上调，miR-10a - 5p 表达受抑制。在顺铂（DDP）耐药的 Huh7 细胞系中，上调 miR-10a - 5p 或敲低 LEF1-AS1 和 MSI1 ...

Here, the authors show that exocrine acinar cells received endocrine β-cell-derived miR-503-322 and caused pancreas autodigestion and anti-proliferation by repressing MKNK1 thereby promoting ...

UFC and Bellator veteran Frank Mir’s comeback with the GFL has been put on hold. That’s because early Monday morning, Mir revealed on Instagram that he recently “underwent an emergency spinal fusion ...

Mazaya 10A is a low-rise residential building in Queue Point. It is a project of Al Mazaya Holding. Queue Point is a collection of 33 low-rise and mid-rise residential buildings located in Liwan, ...

Frank Mir’s proposed Global Fight League debut is likely in jeopardy after he recently underwent emergency spinal surgery. Advertisement The Ultimate Fighting Championship and Bellator MMA ...

Mufti Shah Mir was close to the Jamiat Ulema-e-Islam-F (JUI-F). He previously survived two attempts on his life. The attack came days after two leaders of JUI-F were shot dead in Khuzdar.

Mufti Shah Mir, Muslim scholar who helped Pakistan's ISI in abducting Kulbhushan Jadhav from Iran, shot dead by unknown men. Mufti Shah Mir was killed by unknown gunmen in Balochistan. Mir was ...

After an Ontario Superior Court approved a $32.5-billion national tobacco settlement, Health Canada announced a new framework on Friday to make tobacco companies pay for smoking-related health impacts ...

Curr Gene Ther. 2020. Vol. 20(4):297–312 Fan Q, Meng X, Liang H, Zhang H, Liu X, Li L, et al.. miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell ...

MiRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally contributing to the development of different diseases including cancer. The miR-200 family consists of five ...