目前已发现超过100种RNA修饰，其中大多数发生在转运RNA（tRNA）中，但它们也可以在核糖体RNA（rRNA）、小核RNA（snRNA）、信使RNA（mRNA）和长非编码RNA（ncRNA）中找到。修饰核苷的尿液排泄与多种癌症、艾滋病和其他恶性疾病状态有关。 1-甲基腺苷（m1A）是一种显著 ...

1 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine ...

Yet vaccines using the new technology of mRNA were developed by Moderna and Pfizer/BioNTech in a matter of months, and were already being put into arms by the first anniversary of the pandemic.

这些修饰不仅影响mRNA的稳定性、剪接和翻译，还通过与非编码RNA的相互作用，调节基因表达和细胞行为。 RNA修饰的类型及其功能 目前已鉴定出超过150种RNA修饰类型，其中m?A（N?-甲基腺苷）、m?G（N?-甲基鸟苷）、m?C（5-甲基胞嘧啶）和m1A（N1-甲基腺苷）受到广泛 ...

NSUN2 methylates and stabilizes lncRNA NR_033928, driving cancer progression. E2F1 stimulates NSUN2 expression, while NSUN2 stabilizes ORAI2 mRNA via YBX1, increasing ORAI2 expression. DIAPH2-AS1 ...

“mRNA技术不仅可以做预防性的疫苗，也可以用在肿瘤领域，康希诺在这块也做了一些工作。比如在过去几年，康希诺的上海子公司也一直在探索是否可以开发肿瘤疫苗，最近我们可能会有一些更深的研究。”3月8日，全国政协委员、康希诺生物首席科学官朱涛在 ...

Vaccine skeptics have long-since leveraged the rapid roll out of mRNA vaccines to add fuel to heated arguments surrounding vaccine safety. As a result, a growing share of the public is wary of ...

MRNA technology is facing growing doubts among Republicans. This is a KFF Health News story. Researchers racing to develop bird flu vaccines for humans have turned to a cutting-edge technology ...