Vanishing White Matter Disease (VWMD) affects brain function due to reduced eIF2B activity. New research uncovers how cells ...

研究发现结直肠癌中eIF2B复合物对维持p-eIF2α水平至关重要，敲低eIF2Bα或eIF2Bδ影响细胞存活，且APC缺陷型肿瘤依赖eIF2Bα，干扰该复合物与p-eIF2α的 ...

The therapy, dubbed DNL343, is designed to activate the protein complex eIF2B, protecting neurons by preventing further aggregation of the TDP-43 protein. A phase 2/3 readout from a Massachusetts ...

SOUTH SAN FRANCISCO, Calif., Feb. 27, 2025 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today reported financial results for the fourth quarter and year ended December 31, 2024, and ...

Elevated p-eIF2α, and its proper sensing by the decameric eIF2B complex, are essential to balance translation. Knockdown or mutation of eIF2Bα and eIF2Bδ, two eIF2B subunits responsible for sensing ...

Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B. Vanishing White Matter (VWM) is a neurological disease caused by eIF2B mutations ...