Fonds1 个月
Understanding your public and private IP addresses
Your router has an outward-facing IP address, known as the public IP address, which identifies it on the internet. This is the address that servers see when you browse websites or perform online ...
生物通1 个月
Lactylation 驱动的 FBXO33 激活：胆囊癌转移机制新突破
为探究胆囊癌（GBC）转移机制，研究人员聚焦 FBXO33，发现其促转移机制，为靶向治疗提供新思路。 胆囊癌（Gallbladder cancer，GBC）作为胆道系统中最为常见的恶性肿瘤，一直以来都是医学界难以攻克的难题。它如同隐藏在人体内部的 “定时炸弹”，具有极高的 ...
eLife1 年
Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading
Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to ...
eLife5 年
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS ...
Oligodendrocytes (OLs) myelinate axons and provide electrical insulation and trophic support for neurons in the central nervous system (CNS). Platelet-derived growth factor (PDGF) is critical for ...