Utah State University announced late last week that it will slash instructional and administrative functions to make up for budget cuts imposed by the state Legislature. In the Friday announcement, ...

CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins and endoplasmic reticulum (ER) stress, with activation of the IRE1α-XBP1 pathway that ...

The unfolded protein response (UPR), especially the PERK and IRE1α-XBP1 pathways, emerges as a central regulator of protein synthesis and ER stress management. The review also discusses the role of ...

On 19th February 2025, UNPO participated in the UPR Info Pre-Session on Lao PDR in Geneva, delivering a statement on behalf of the Hmong people. UNPO highlighted the severe human rights violations ...

"Long live independent film!" That's how Anora director Sean Baker ended his speech on Sunday night after accepting the award for best picture. The screwball dramedy's indie credentials were ...

Paneth细胞和杯状细胞对抗菌防御和粘液分泌至关重要，其功能障碍与UPR缺陷有关，导致生态失调和炎症反应加剧。 X-box结合蛋白1（XBP1）是IRE1通路激活的转录因子，对维持IEC功能至关重要。该研究的实验模型显示，肠道上皮中XBP1缺失导致自发性炎症，增加对细菌 ...

Cells produce many protein molecules. These are made of chains of building blocks called amino acids that then fold into three-dimensional shapes. Specialist proteins known as chaperones assist this ...

Endoplasmic reticulum (ER) stress is implicated in many chronic diseases, but very little is known about how the unfolded protein response (UPR) responds to persistent ER stress in vivo. Here, we ...