Phase 1 dose-escalation study continues with data readout expected mid-2025; Dose expansion data readout anticipated 1H 2026 Mecbotamab vedotin (CAB-AXL-ADC) Q2W dosing regimen associated with ...

为了攻克这一难题，宁夏医科大学的研究人员展开了深入研究。他们将目光聚焦在 Wnt5a 这个神秘的因子上，致力于探究它在 CRPC 中扮演的角色。研究成果发表在了《Journal of Translational Medicine》杂志上。

研究人员为探究结直肠癌（CRC）中 CAFs 与肿瘤细胞作用机制，开展多组学研究，发现 CTHRC1 + CAF-WNT5A-MSLN 轴，为治疗提供新策略。 在癌症的 “战场” 上，结直肠癌（Colorectal Cancer，CRC）可谓是一位 “劲敌”。它是全球第三大常见癌症，近年来发病率和死亡率一直 ...

Background: Circular RNAs (circRNAs) have been recently proposed as hub molecules in various diseases, especially in tumours. We found that circRNAs derived from ribonuclease P RNA component H1 (RPPH1 ...

Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells ...

Dendritic cells (DCs) control the strength and quality of antigen-specific adaptive immune responses. This is critical for launching a robust immunity against invading pathogens while maintaining a ...

Wnt5a has been implicated in melanoma progression and metastasis, although the exact downstream signaling events that contribute to melanoma metastasis are poorly understood. Wnt5a signaling results ...