研究结论和讨论部分指出，该研究揭示了孕期小鼠感染 P. gingivalis 导致子代 CP 的机制，即 P. gingivalis 通过增强糖酵解和 H 4 K12la，上调 ADAM17，进而裂解 TGFBR1 和 MerTK，影响腭部融合和骨化。这一发现为解释母亲牙周疾病与子代 CP 的关联提供了理论依据，也为预防 ...

Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada (B.S., M.X.D., J.C.Y.C., M.O.). Division of ...

The peculiar behaviour of this rare self-healing cancer, called multiple self-healing squamous epithelioma (MSSE), was discovered to be caused by a failure in the gene called TGFBR1, which is a key ...

避免AI幻觉的核心是：以严格筛选的数据和经深度治理的知识对模型的推理过程进行约束。 “孩子未满14岁，此前因扁平足、足踝外翻等结缔组织 ...

Genetic testing of the 10 LDS-associated genes in the two probands showed that c.605C>T (JX001-II1) and c.679G>A (JX002-II1) variants were both positioned in exon 1 of TGFBR1 and it results in the ...

Shprintzen–Goldberg syndrome (SGS) is a multisystemic connective tissue disorder, with considerable clinical overlap with Marfan and Loeys–Dietz syndromes. These syndromes have commonly been ...

Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease ...