NEDD4L敲除加剧了由硫酸葡聚糖钠(DSS)和2,4,6-三硝基苯磺酸(TNBS)诱导的结肠炎以及由偶氮甲烷和DSS诱导的CRC。从机制上讲，IEC中NEDD4L的缺乏通过降低SLC3A2的蛋白质表达而不影响其基因表达，从而抑制了关键铁死亡调节因子GPX4的表达，最终促进了DSS诱导的IEC铁死亡(图 ...

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the aggregation of α-synuclein. Neuroinflammation is triggered by the ...

Ferroptosis represents a distinct form of cell death that is not associated with necrosis, autophagy, apoptosis, or pyroptosis. It is characterised by intracellular iron-dependent lipid peroxidation.