宁波大学附属第一医院的研究人员勇挑重担，开展了一项意义重大的研究。他们将目光聚焦于信号转导与转录激活因子（STAT）家族，这个家族在细胞周期、免疫反应和肿瘤发展过程中发挥着至关重要的作用，可其在结直肠癌中的功能和表达情况此前却并不明确。研究人员经过深入探索，发现 STAT3 和 STAT5B ...

This is an important study that characterizes a surprising interaction between two different cytokine/hormone receptors using nanoscale resolution (dSTORM) microscopy. The study provides solid ...

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...

研究亮点 遗传与分子机制解析：T-PLL 相关的 t(X;14)(q28;q11.2) 易位及 STAT5B 突变的鉴定。 现有治疗策略：Alemtuzumab 仍是标准一线治疗，但疗效受限。 新兴疗法：JAK/STAT 抑制剂有望成为 T-PLL 的新型靶向治疗手段。 研究结论 T-PLL 是一种具有高度侵袭性且预后较差的 ...

Following PRL exposure, the STAT5 isoform, STAT5B, is preferentially activated and there is a significant upregulation in the secretion of pro-inflammatory cytokines, IL-6 and IL-1β. This inflammatory ...

Background: The signal transducer and activator of transcription (STAT) protein family, a group of seven members (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6), has been widely used to ...

Despite antigen affinity of B cells varying from cell to cell, functional analyses of antigen-reactive B cells on individual B cells are missing due to technical difficulties. Especially in the field ...