For example, significant hepatic lipid accumulation is observed in a mouse model in which the hepatocyte histone methyltransferase Setdb1 is knocked out. In this process, upregulated miR-216b-5p binds ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

A new review was published in Oncotarget, Volume 16, on February 12, 2025, titled “SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types.” Authors ...

Here, we reveal that HCMV latency in human CD34 + HSC reflects the recruitment on the viral genome of KAP1, a master co-repressor, together with HP1 and the SETDB1 histone methyltransferase, which ...