Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, United States ...

Yamamoto and Matano provide convincing evidence that a G63E/R CD8+ T-cell escape mutation in the accessory viral protein Nef promote the induction of neutralizing antibody (nAb) responses in rhesus ...

This month's cover highlights the article Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice by Nicolas Toni, Thomas Larrieu and colleagues.

Our research centres upon understanding the molecular underpinnings of why some patients respond to therapies – in particular standard-of-care chemotherapeutics – whilst others do not, and using this ...

The Interferon (IFN) Induced Helicase C domain 1 gene IFIH1 gene encodes the Melanoma Differentiation–Associated protein 5 (MDA5), which belongs to the RIG-I-Like Receptors (RLRs) family, a group of ...

Our team has identified the protein SAMHD1 as major resistance factor to cytarabine (ara-C) and other nucleoside analogues, a class of chemotherapeutic drugs that are used in the treatment of both ...

We show that AhR activation in macrophages causes a block to HIV-1 and HSV-1 replication. We find that AhR activation transcriptionally represses cyclin-dependent kinase (CDK)1/2 and their associated ...