PI3K 抑制剂能否解乳腺癌内分泌治疗耐药的燃眉之急？以 PI3K 抑制剂为基础的联合治疗对于内分泌耐药人群的治疗前景如何？本文中，笔者与您一同来探讨这些问题，旨在为临床诊疗提供思路与启发。

ALK抑制剂 ALK 全称叫做间变性淋巴瘤激酶，是一种RTKs，属于胰岛素受体超家族。ALK 引发肿瘤的主要原因是染色体易位导致的 ALK 基因重排，进而和 ...

While intracellular receptors for JH are well characterized, membrane receptors for JH have remained elusive for many years. The authors provide convincing evidence indicating that two receptor ...

哈尔滨工业大学全媒体中心编审 技术支持：哈尔滨工业大学网络安全和信息化办公室 ...

Receptor tyrosine kinases (RTKs) are pivotal in both normal cellular functions and cancer progression, activating critical signaling pathways. In cancer therapy, targeted therapies using monoclonal ...

In this study, the authors screened all RTKs from the H. armigera genome for their ability to mediate responses to JH III treatment both in cultured cells and in developing animals. They also present ...

TCPTP regulates diverse signaling pathways by dephosphorylating distinct substrates [e.g., Janus activated kinase (JAK), Signal Transducer and Activator of Transcription (STAT), and Receptor Tyrosine ...

Introduction: Aberrant activation of Semaphorin3C(SEMA3C) is widespread in human cancers. We aimed to analyze SEMA3C expression in cervical cancer and investigate the role of SEMA3C in cervical cancer ...