Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

它身兼数职，既参与激活细胞周期蛋白依赖性激酶（CDK），调控细胞周期进程，又作为转录因子 IIH（TFIIH）复合物的一部分，对 RNA 聚合酶 II（RNAPII）转录发挥调节作用。然而，自上世纪 90 年代以来，一个令人困惑的问题一直困扰着科学家们：CDK7 对细胞周期 CDK ...

Our results demonstrate that p53 and RNAPII mediate extensive chromatin interactions within the Ad-p53 vector, resulting in the formation of a distinct 3D structure characterized by three prominent ...

Chromatin structural domains, or topologically associated domains (TADs), are a general organizing principle in chromatin biology. RNA polymerase II (RNAPII) mediates multiple chromatin interactive ...

RNA polymerase (RNAPII) transcription occurs pervasively, raising the important question of its functional impact on other DNA-associated processes, including replication. In budding yeast, ...

2011). We therefore took an unbiased approach to map the tSH2 domain binding site within RNAPII and, contrary to the earlier assumptions, found that Spt6 tSH2 directly binds the flexible, 86 residue ...