Pepinemab is a humanized IgG4 monoclonal antibody designed to block SEMA4D, which can bind to plexin-B1 receptors to trigger collapse of the actin cytoskeleton in cells and lead to loss of ...

CWRU medical students will present their work in the subsequent School of Medicine Student Research Day (formerly Lepow Day) event. Protein-Protein Interactions in Cell Signaling of small GTPases, ...

Anti-PIT1 hypophysitis is a form of paraneoplastic autoimmune hypophysitis. The condition is attributable to the ectopic expression of pituitary-specific positive transcription factor 1 (PIT1) in ...

Therefore, Sema-Plexin may utilize a specific downstream signaling cascade to control neurite pruning that differs from its roles in axon guidance and synapse formation. Neurite pruning also plays a ...

Introduction: Aberrant activation of Semaphorin3C(SEMA3C) is widespread in human cancers. We aimed to analyze SEMA3C expression in cervical cancer and investigate the role of SEMA3C in cervical cancer ...

Proper connectivity of the nervous system requires temporal and spatial control of axon guidance signaling. As commissural axons navigate across the CNS midline, ROBO-mediated repulsion has ...