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15 天
RAC1:舌鳞状细胞癌治疗新希望?研究揭示关键作用与潜在靶点
RAC1 沉默抑制 PAK1/LIMK1 信号通路激活:敲低 RAC1 后,PAK1、LIMK1 的 mRNA 和蛋白表达水平以及 PAK1 和 LIMK1 的磷酸化水平均显著下降,说明 RAC1 沉默可抑制该信号通路激活。 RAC1 沉默抑制体内肿瘤生长:将敲低 RAC1 的 CAL27 细胞接种到裸鼠体内,发现 shRAC1 组肿瘤生长 ...
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