13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food ...

SUZHOU, China, March 27, 2025 /PRNewswire/ -- CStone Pharmaceuticals ("CStone", HKEX: 2616), a biopharmaceutical company dedicated to developing innovative cancer therapies, today reported 2024 annual ...

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth ...

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

Avapritinib is a small molecule that crosses the blood-brain-barrier and targets platelet derived growth factor alpha (PDGFRA ...

在一项新的研究中，来自密歇根大学、丹娜法伯癌症研究院和维也纳医科大学的研究人员发现PDGFRA基因发生DNA改变的高分级胶质瘤肿瘤细胞对药物阿伐替尼（avapritinib）有反应，其中该药物已被美国食品药品管理局（FDA）批准用于治疗PDGFRA外 ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric ...

脑肿瘤仍然是儿童癌症死亡的最常见原因。特别是小儿高级胶质瘤（pHGG）是一种主要致命的疾病组，诊断后的中位生存时间不到18个月，治疗选择有限。来自维也纳MedUni /维也纳大学医院、丹娜-法伯癌症研究所和密歇根大学医学院的一个研究小组发现，血小板衍生生长因子受体α (PDGFRA)是一种很有前途的治疗方法。这项研究刚刚发表在科学杂志《癌细胞》上。

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