有很多朋友好奇我们在研究前列腺癌时，如何使用或者构建动物模型。今天就和大家介绍一种我们常用的小鼠模型TRAMP小鼠，通过这种鼠了解一些特殊的前列腺癌。前列腺癌常用小鼠模型常见模型主要包括异种移植模型和基因小鼠模型。异种移植模型将人前列腺癌细胞或患者来 ...

为解决乳腺癌早期诊断难题，研究人员整合生物信息学与机器学习，确定 6 个关键基因，构建可靠诊断模型，助力改善预后。 乳腺癌诊断的困境与探索：新研究带来的曙光 乳腺癌，作为女性健康的 “头号杀手” 之一，在全球范围内的发病率和死亡率都令人担忧。

为探究衰老细胞中基因组不稳定与炎症的关联，研究人员聚焦 p53，发现其可抑制 CCF 积累及炎症，或为衰老相关疾病治疗提供新靶点。 在生命的长河中，衰老就像一个无法避免的 “关卡”，它带来了身体机能的衰退，还让我们更容易患上各种疾病。随着年龄的 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The DREAM repressor complex regulates genes ...

Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China Introduction: The recombinant human p53 adenovirus (Ad-p53) offers a ...

Introduction: There are about 2,300,000 new cases of breast cancer worldwide each year. Breast cancer has become the first most common cancer in the world and the leading cause of death among women.

The MCM2–7 hetero-hexamer is the replicative DNA helicase that plays a central role in eukaryotic DNA replication. In proliferating cells, the expression level of the MCM2–7 hexamer is kept high, ...

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which ...