健康元切入镇痛赛道，Nav1.8抑制剂拓展慢病生态协同边界
在创新药加速向机制升级、适应症精准拓展演进的趋势下，健康元药业在其呼吸系统疾病治疗主线之外，开始布局多元化创新领域。公司针对 ...
生物通6 天
标题：探秘钠通道 1.8（NaV1.8）阻断剂苏西曲吉宁（VX-548），解锁疼痛 ...
为探索 Na V 1.8 相关治疗，研究人员研究苏西曲吉宁（VX-548），发现其为 Na V 1.8 阻断剂，意义重大。
亿欧数据 on MSN13 天
Latigo Biotherapeutics完成B轮融资，多家知名投资方参与
Latigo Biotherapeutics，一家专注于非阿片类止痛药研发的创新型公司，近日完成了B轮融资。此轮融资由5AM Ventures、Access ...
Frontiers19 天
The potential role and mechanism of Rhizoma Coptidis in prevention of diabetic ...
Active compounds in RC, berberine and coptisine, were found to ameliorate HT22 injury induced by high glucose. Network pharmacology results suggest that voltage-gated sodium channel subtypes (Nav1.1, ...
Florida Today22 天
SpaceX Falcon 9 rocket raised on KSC Pad 39A ahead of NASA's Crew-10 launch
SpaceX is reviewing data from the recent incidents to improve the reliability of future Falcon 9 flights. (Updates with the latest information) SpaceX's Falcon 9 rocket is upright on its Kennedy ...
Financial Post1 个月
Xenon Reports Fourth Quarter & Full Year 2024 Financial Results and Business Update
– Phase 3 topline data from azetukalner FOS epilepsy program planned for H2 2025 in support of NDA filing and potential commercial launch ...
Rotten Tomatoes10 个月
Plan 9 From Outer Space
Wolf Hall: The Mirror and the Light: Season 2 Link to Wolf Hall: The Mirror and the Light: Season 2 All Marvel Movies In Order: How To Watch MCU Chronologically Link to All Marvel Movies In Order ...
Frontiers2 年
Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain
Nav1.8 is a voltage-gated sodium channel (VGSC ... [STdr]; and −1.55 mm (AP), +3.0 mm (ML) −4.9 mm (DV) [CeA]. We injected a total of 1,000 nL of viral suspension at an injection rate of 100 nL/min.
eLife5 年
The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal ...
The brain contains around 100 billion neurons that are in constant communication with one another. Each consists of a cell body, plus two components specialized for exchanging information. These are ...