Researchers explore how natural compounds in traditional Chinese medicine can modulate cholesterol metabolism to combat ...

肥胖问题日益严峻，为探究肠道 IL-25 在高脂饮食（HFD）诱导肥胖中的作用，研究人员开展相关研究。结果发现，HFD 小鼠肠道 IL-25 表达降低，过表达 IL-25 可改善代谢。该研究为肥胖相关代谢疾病治疗提供新方向。

本文揭示胰腺癌（PAAD）细胞通过过表达 NPC1L1 抑制 CD8 + T 细胞功能，NPC1L1 可作为治疗靶点改善 PAAD 免疫治疗效果。 引言 在癌症研究领域，CD8 + T 细胞在抗肿瘤免疫中占据着至关重要的地位，然而肿瘤细胞常常会施展多种免疫抑制策略来逃避 CD8 + T 细胞的监控 ...

Mechanistically, ezetimibe works by binding to NPC1L1, which is a key mediator of cholesterol absorption. Accumulating data from preclinical models have shown that ezetimibe alone could inhibit the ...

Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular entry of Ebola virus. Cholesterol export is ...

2012), though the significance of the findings on the effect of curcumin against oxidant and lipid-induced damage needs to be further studied. Intestinal Niemann-Pick C1-like 1 (NPC1L1) cholesterol ...