Scientists at The Institute of Cancer Research in London have made significant strides in understanding why some cases of neuroblastoma—a pedia ...

The Fellows of the AACR Academy have elected Elaine V. Fuchs, PhD, FAACR, as their next President. She will assume the ...

研究人员为开展此项研究，主要运用了以下关键技术方法：从 TARGET 和 FerrDb 数据库获取数据，运用 R 语言软件进行差异分析，筛选出相关差异表达基因（DEGs）；通过单变量 COX 分析、Lasso 回归分析和多变量 COX 分析构建预后模型并计算风险评分；利用 CIBERSORT 分析高风险（HR）和低风险（LR）人群免疫细胞浸润（ICI）差异；采用细胞实验和实时荧光定量 ...

Neuroblastoma, an aggressive malignancy originating from neural crest cells, accounts for 15% of cancer-related deaths in children. Treatment strategies include systemic chemotherapy, radiation or ...

研究针对 MYCN 扩增型神经母细胞瘤治疗难题，探究 FAM13A 与 N-Myc 作用，发现 FAM13A 或为潜在治疗靶点。 研究背景：攻克难题，探索新靶点 神经母细胞瘤（Neuroblastoma，NB）是一种常见于婴幼儿时期的神经内分泌肿瘤，起源于神经嵴细胞。它在儿童癌症相关死亡中占 ...

撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化-蛋白酶体系统快速降解，在MYCN扩增的NB细胞中，Aurora-A激酶与SCF-Fbxw7 ...

Background: MYCN is an oncogenic transcription factor of the MYC family and plays an important role in the formation of tissues and organs during development before birth. Due to the difficulty in ...

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9Department of Chemistry, University of Missouri, Columbia, Missouri. 10Department of Radiology, University of Missouri, Columbia, Missouri. Search for other works by this author on: 3Molecular ...

The marquee NBA Thursday night matchup is set between the Milwaukee Bucks and the visiting Denver Nuggets. Both teams hold top-five seeds in their respective conferences, as the Nuggets are on ...

In trading on Friday, shares of XPO Inc (Symbol: XPO) crossed below their 200 day moving average of $122.93, changing hands as low as $116.86 per share. XPO Inc shares are currently trading off ...