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打破常规:组蛋白回收异常如何搅乱细胞命运,威胁细胞生存?
像组蛋白 H3 - H4 会以四聚体,甚至可能以六聚体的形式,与单个 H2A/H2B 二聚体一起进行回收。并且,复制体因子 Tof1/TIMELESS、微小染色体维持复合体组件 2(MCM2)、Ctf4 以及 DNA 聚合酶 α(POLA1)和 δ(POLD)对于后随链上高效的组蛋白回收是必需的,而 DNA 聚合酶 ...
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