Figure 1: Dnmt1 actively represses transcription using sequences that overlap the HRX repression domain. Figure 2: Dnmt1 686–812 represses transcription in a TSA-sensitive manner and has the ...

为精准诊断和预测肝细胞癌（HCC）预后，研究人员探究相关生物标志物，发现 FOLR1 可作诊断和预后指标。 肝细胞癌（Hepatocellular carcinoma，HCC）是一种严重威胁人类健康的恶性肿瘤，它如同隐藏在身体里的 “定时炸弹”，悄无声息地给人们带来致命危机。

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The DREAM repressor complex regulates genes ...

为探究 CHD8 在自闭症相关细胞中的功能，研究人员发现 CHD8 与 TRRAP 相互作用，共同调控 MYC 和 E2F 靶基因，影响细胞周期，这一成果为理解自闭症发病机制提供新视角。 # 探秘神经干细胞调控密码：CHD8-TRRAP 轴的关键作用 在神秘的神经科学领域，自闭症一直是 ...

Introduction: Lung adenocarcinoma (LUAD) therapies are plagued by insufficient immune infiltration and suboptimal immune responses in patients, which are closely associated with the hyperactive ...

Background: MYCN is an oncogenic transcription factor of the MYC family and plays an important role in the formation of tissues and organs during development before birth. Due to the difficulty in ...

The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, ...

Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the ...