总的来说，这项研究是中国首次针对结直肠息肉病遗传谱的多中心临床研究。它不仅建立了中国结直肠息肉病数据库，还揭示了中国人群结直肠息肉病遗传变异谱的特征，发现与国外研究在 APC 突变率和突变类型上存在差异。研究结果为中国结直肠息肉病患者的临床诊断、治疗和遗传咨询提供了重要依据，也为进一步探索结直肠息肉病的发病机制奠定了基础，有助于推动精准肿瘤学在结直肠息肉病领域的发展。

Background and aims Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1–2 years. However, ...

Assessing Clinical Value of New Treatment Strategies: ESMO-MCBS and ASCO-VF Evaluation in Phase III Trials at ASCO Annual Meeting 2022 Demand for germline hereditary cancer genetic testing has ...

Chimeric RNA landscape in the Chinese population and the role of SFT2D2-TBX19 in prostate cancer progression. Risk stratification using the Decipher 22-gene genomic classifier (GC) and digital ...