为了攻克这一难题，苏州大学附属苏州医院的研究人员开展了一项极具意义的研究。他们致力于寻找与奥沙利铂耐药相关的基因（OXARGs），并深入探究这些基因在胃癌奥沙利铂耐药中的作用和机制。研究成果发表在《Molecular Medicine》杂志上，为胃癌的治疗带来了新的希望。

深入机制研究发现，HIF-1α通过双重防御体系维持铜稳态：一方面下调线粒体三羧酸循环关键酶DLAT表达，减少铜离子在线粒体基质中的蓄积；另一方面诱导金属硫蛋白MT2A过量表达，其每分子可螯合7个铜离子的特性，形成细胞质铜缓冲池。这种立体防御网络使肿瘤 ...

Cutaneous squamous cell carcinoma (cSCC) is the second most frequent of the keratinocyte-derived malignancies with actinic keratosis (AK) as a precancerous lesion. To comprehensively delineate the ...

Musculoskeletal tissue degeneration impairs the life quality and function of many people. Meniscus degeneration is a major origin of knee osteoarthritis and a common threat to athletic ability, but ...

Bilateral renal cell carcinoma (RCC) is a rare disease that can be classified as either familial or sporadic. Studying the cellular molecular characteristics of sporadic bilateral RCC is important to ...