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28 天
子宫内膜癌非热点POLE突变该如何解读?基因组特征与热点POLE突变 ...
迄今为止,已有11种POLE致病性变异被认定为“热点”突变。以POLE热点突变(POLEmut)为特征的子宫内膜癌(EC)患者具有极佳的生存预后。尽管国际指南建议对早期POLEmut型EC患者减少辅助治疗的强度,但关于具有不良特征的POLEmut患者接受这种治疗的安全性数据仍 ...
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