为探究 4 - 乙烯基环己烯二氧化物（VCD）对卵巢自噬的影响，研究发现其下调 IGF1R 引发过度自噬致卵巢早衰，意义重大。 研究人员主要运用了以下几种关键技术方法：通过构建小鼠模型，给 6 周龄的 C57BL/6 小鼠连续 15 天腹腔注射 VCD，模拟卵巢早衰情况；使用细胞培养技术培养人颗粒细胞样肿瘤细胞系 KGN 细胞，并对其进行 VCD 处理；采用转录组测序（RNA-Seq）分析 VCD ...

This review discusses the complex molecular pathogenesis of ACC, focusing on critical pathways implicated in the tumorigenesis and providing potential targets for therapy: the Wnt/β-catenin signaling ...

研究人员为探究安第斯和喜马拉雅人群适应高海拔遗传机制，分析基因组数据，发现趋同演化及相关基因通路，意义重大。 在地球的高海拔地区，稀薄的空气如同神秘的面纱，笼罩着独特的生命适应故事。长期以来，生活在高海拔的安第斯和喜马拉雅人群如何 ...

Methods: We used a hypertension-based model of cerebrovascular dysfunction in mice with VSMC-specific IGF-1 receptor (Igf1r) deficiency and evaluated the development of cerebrovascular pathologies and ...

The authors identified the IGF1-IGF1R ligand-receptor pair as a factor involved in the macrophage-mediated induction of memory-like Th17 cells, as confirmed by experiments using an IGF1R inhibitor.

As a well-recognized environmental contaminant, lead (Pb) represents a profound threat to human health, with the nervous system being especially vulnerable. Pb exerts its toxic effects through a range ...

Purple Biotech's NT219 is a first-in-class small molecule drug designed to target key cancer resistance mechanisms by degrading IRS1/2 and blocking IGF1R/IRS1 and STAT3 survival pathways, ...

Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells ...