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4 天
Microglia、IRF5 与多发性硬化症:脂质代谢调控与疾病治疗新靶点
多发性硬化症(MS)发病机制不明,炎症性小胶质细胞活动贯穿病程。研究人员围绕小胶质细胞中干扰素调节因子 5(IRF5)展开研究。结果发现 IRF5 对髓鞘降解和胆固醇稳态至关重要,或可成为治疗 MS 的潜在靶点,为相关治疗提供新思路。
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