研究人员围绕 IS 与焦亡展开了一系列深入研究，最终在《BMC Medical Genomics》上发表了重要成果。他们发现 Irf1、Icam1、Tlr2、Cebpb 和 Il1rn 这几个基因，是与 CIRI 焦亡密切相关的枢纽基因，而且这些基因与不同免疫细胞存在关联。这一发现意义重大，为从焦亡角度 ...

This important study describes a first-in-human trial of autologous p63+ stem cells in patients with idiopathic pulmonary fibrosis, a lethal condition for which effective treatments are lacking. The ...

This important study describes a first-in-human trial of autologous p63+ stem cells in patients with idiopathic pulmonary fibrosis, a lethal condition for which effective treatments are lacking. The ...

这些差异包括了炎症反应、免疫功能、细胞黏附、蛋白水解及凋亡等多个生物过程。进一步地，在独立的生物样本库中通过ELISA和Olink平台验证了四种蛋白质（CHI3L1、GDF15、IL1RN和SELE）作为HCC的候选标志物。这四种蛋白的组合在预测HCC风险上表现出比传统风险因素 ...

In the training cohort of TCGA-THCA, we conducted LASSO regression analysis (Figures 6A,B), screening out 8 key genes (AZU1, COL3A1, CP, CSF2, F12, GNA14, IL1RN, and SERPIND1). Using stepwise ...

Liver was perfused through the vena cava with 10 ml ice-cold PBS. During perfusion, the hepatic portal vein was cut to allow outflow of the blood from the liver. Afterwards, liver was gently meshed ...