The course for the 2025 Saxo Classic includes 17 'bergs' and several sections of cobblestone roads across the 208.6 kilometre route from Harelbeke and back. The route heads east through Oudenaarde ...

PROteolysis TArgeting Chimeras (PROTACs) are small molecules that induce target protein degradation via the ubiquitin-proteasome system. PROTACs recruit the target protein and E3 ligase; a critical ...

Accumulating evidence indicates that UPS, which consists of E1, E2, and E3 enzymes and proteasome, plays an important role in the GC tumorigenesis. The imbalance of UPS impairs the protein homeostasis ...

So far, many ubiquitin E3 ligases anchored in the membrane system have been identified as critical players ... which induces the damage of cell target during apoptosis and is challenging to be ...