Figure 1: a, Baseline in vivo tracings of left ventricular (LV) pressure (upper) and the first derivative of ventricular pressure (dP/dt; lower) for young and older mice in both groups. Figure 2 ...

Hypertrophic cardiomyopathy (HCM) is an uncommon disease with significant consequences. Since the 1950s, major strides in understanding its etiology and pathogenesis have led to improved ...

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS ...

The patients were selected so as to encompass all who were known to have radiographic evidence of renal osteodystrophy (five patients, Table 1). Patients were also selected to ensure availability ...

Request permissions for this article. Department of Cardiology, Heart Centre (A.A.R., K.R., A.H.C., H.B., F.G.), Copenhagen University Hospital–Rigshospitalet ...