并且，研究确定了四个 Hippo 通路经典基因（CCDC80、GADD45A、F3 和 TGFB2），它们在 HR 阳性乳腺癌队列中，高表达与患者生存改善显著相关。这些发现为 HDACi 在 HR 阳性乳腺癌中的临床应用提供了新的理论依据，有助于开发更有效的治疗策略，改善患者预后。该研究 ...

Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and the pathogenic mechanism is still unclear, mostly related to genetics, immunity, inflammation, and abnormal activation ...

Skeletal muscle adapts to exercise by improving metabolism and structure, leading to elevated performance. The identification of multiple signaling pathways that contribute to muscle adaptation ...

Skeletal muscle exhibits remarkable plasticity in response to environmental cues, with stress-dependent effects on the fast-twitch and slow-twitch fibers. Although stress-induced gene expression ...