135㎡精装房大改造：三代同堂
135㎡精装房大改造：三代同堂 ...
C&EN21 天
Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way ...
Institute of Medical Microbiology and Hygiene and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University, Mainz 55131, Germany Institute of Infection ...
Nature1 个月
Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic
In this proof-of-concept work, the researchers used cells that expressed the HaloTag–FKBP fusion protein as a stand in for a cancer marker. Their first RIPTACs consisted of a ligand that bound ...
Frontiers4 年
The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions
Figure 4. A new approach enables spatiotemporal manipulation of tubulin PTMs in living cells. Typically, FRB (R) can be anchored to the region of interest with the help of a specific targeting motif, ...
eLife4 年
chTOG is a conserved mitotic error correction factor
Accurate chromosome segregation requires kinetochores on duplicated chromatids to biorient by attaching to dynamic microtubules from opposite spindle poles, which exerts forces to bring kinetochores ...
eLife8 年
Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca
All cells need calcium ions to stay healthy, but having too many calcium ions can interfere with important processes in the cell and cause severe problems. Proteins known as calcium channels on the ...